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Therapeutic B cell depletion impairs adaptive and autoreactive CD4(+) T cell activation in mice
CD20 antibody depletion of B lymphocytes effectively ameliorates multiple T cell-mediated autoimmune diseases through mechanisms that remain unclear. To address this, a mouse CD20 antibody that depletes >95% of mature B cells in mice with otherwise intact immune systems was used to assess the rol...
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| Auteurs principaux: | , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2007
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2409235/ https://ncbi.nlm.nih.gov/pubmed/18093919 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0709205105 |
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