Amplified B Lymphocyte CD40 Signaling Drives Regulatory B10 Cell Expansion in Mice

BACKGROUND: Aberrant CD40 ligand (CD154) expression occurs on both T cells and B cells in human lupus patients, which is suggested to enhance B cell CD40 signaling and play a role in disease pathogenesis. Transgenic mice expressing CD154 by their B cells (CD154(TG)) have an expanded spleen B cell po...

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Bibliografiske detaljer
Main Authors: Poe, Jonathan C., Smith, Susan H., Haas, Karen M., Yanaba, Koichi, Tsubata, Takeshi, Matsushita, Takashi, Tedder, Thomas F.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3143148/
https://ncbi.nlm.nih.gov/pubmed/21799861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0022464
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