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Amplified B Lymphocyte CD40 Signaling Drives Regulatory B10 Cell Expansion in Mice
BACKGROUND: Aberrant CD40 ligand (CD154) expression occurs on both T cells and B cells in human lupus patients, which is suggested to enhance B cell CD40 signaling and play a role in disease pathogenesis. Transgenic mice expressing CD154 by their B cells (CD154(TG)) have an expanded spleen B cell po...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3143148/ https://ncbi.nlm.nih.gov/pubmed/21799861 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0022464 |
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