Interference with PPARγ Signaling Causes Cerebral Vascular Dysfunction, Hypertrophy, and Remodeling

The transcription factor PPARγ is expressed in endothelium and vascular muscle where it may exert anti-inflammatory and anti-oxidant effects. We tested the hypothesis that PPARγ plays a protective role in the vasculature by examining vascular structure and function in heterozygous knockin mice expre...

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Hauptverfasser: Beyer, Andreas M., Baumbach, Gary L., Halabi, Carmen M., Modrick, Mary L., Lynch, Cynthia M., Gerhold, Thomas D., Ghoneim, Shams M., de Lange, Willem J., Keen, Henry L., Tsai, Yau-Sheng, Maeda, Nobuyo, Sigmund, Curt D., Faraci, Frank M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2408877/
https://ncbi.nlm.nih.gov/pubmed/18285614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.107.103648
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