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Eradication of pathogenic β-catenin by Skp1/Cullin/F box ubiquitination machinery
The use of Skp1/Cull 1/F box (SCF) ubiquitin-conjugation machinery as a potential knockout tool offers a means of eradicating disease-causing proteins. Here a chimeric F box protein (CFP) was engineered to achieve selective eradication of pathogenic β-catenin in colorectal cancer. We show that CFP s...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC240686/ https://ncbi.nlm.nih.gov/pubmed/14563921 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2133261100 |
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