Blastic transformation of p53-deficient bone marrow cells by p210(bcr/abl) tyrosine kinase

Blastic transformation of chronic myelogenous leukemia (CML) is characterized by the presence of nonrandom, secondary genetic abnormalities in the majority of Philadelphia(1) clones, and loss of p53 tumor suppressor gene function is a consistent finding in 25–30% of CML blast crisis patients. To tes...

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Autores principales: Skorski, Tomasz, Nieborowska-Skorska, Malgorzata, Wlodarski, Pawel, Perrotti, Danilo, Martinez, Robert, Wasik, Mariusz A., Calabretta, Bruno
Formato: Artigo
Lenguaje:Inglês
Publicado: The National Academy of Sciences of the USA 1996
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC24059/
https://ncbi.nlm.nih.gov/pubmed/8917557
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