Blastic transformation of p53-deficient bone marrow cells by p210(bcr/abl) tyrosine kinase

Blastic transformation of chronic myelogenous leukemia (CML) is characterized by the presence of nonrandom, secondary genetic abnormalities in the majority of Philadelphia(1) clones, and loss of p53 tumor suppressor gene function is a consistent finding in 25–30% of CML blast crisis patients. To tes...

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Bibliographic Details
Main Authors: Skorski, Tomasz, Nieborowska-Skorska, Malgorzata, Wlodarski, Pawel, Perrotti, Danilo, Martinez, Robert, Wasik, Mariusz A., Calabretta, Bruno
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences of the USA 1996
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC24059/
https://ncbi.nlm.nih.gov/pubmed/8917557
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