Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway.

The BCR/ABL oncogenic tyrosine kinase activates phosphatidylinositol 3-kinase (PI-3k) by a mechanism that requires binding of BCR/ABL to p85, the regulatory subunit of PI-3k, and an intact BCR/ABL SH2 domain. SH2 domain BCR/ABL mutants deficient in PI-3k activation failed to stimulate Akt kinase, a...

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Detalhes bibliográficos
Main Authors: Skorski, T, Bellacosa, A, Nieborowska-Skorska, M, Majewski, M, Martinez, R, Choi, J K, Trotta, R, Wlodarski, P, Perrotti, D, Chan, T O, Wasik, M A, Tsichlis, P N, Calabretta, B
Formato: Artigo
Idioma:Inglês
Publicado em: 1997
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1326299/
https://ncbi.nlm.nih.gov/pubmed/9321394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/16.20.6151
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