In Vitro Activation of the IκB Kinase Complex by Human T-cell Leukemia Virus Type-1 Tax

Human T-cell leukemia virus type-I expresses Tax, a 40-kDa oncoprotein that activates IκB kinase (IKK), resulting in constitutive activation of NFκB. Herein, we have developed an in vitro signaling assay to analyze IKK complex activation by recombinant Tax. Using this assay in combination with repor...

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Bibliografiske detaljer
Main Authors: Mukherjee, Sohini, Negi, Veera S., Keitany, Gladys, Tanaka, Yuetsu, Orth, Kim
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2008
Fag:
Mechanisms of Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2397464/
https://ncbi.nlm.nih.gov/pubmed/18223255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M704831200
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