Structural Requirements for Yersinia YopJ Inhibition of MAP Kinase Pathways

MAPK signaling cascades are evolutionally conserved. The bacterial effector, YopJ, uses the unique activity of Ser/Thr acetylation to inhibit the activation of the MAPK kinase (MKK) and prevent activation by phosphorylation. YopJ is also able to block yeast MAPK signaling pathways using this mechani...

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Main Authors: Hao, Yi-Heng, Wang, Yong, Burdette, Dara, Mukherjee, Sohini, Keitany, Gladys, Goldsmith, Elizabeth, Orth, Kim
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2008
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2147050/
https://ncbi.nlm.nih.gov/pubmed/18167536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0001375
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