Structural requirements for Yersinia YopJ inhibition of MAP kinase pathways.

MAPK signaling cascades are evolutionally conserved. The bacterial effector, YopJ, uses the unique activity of Ser/Thr acetylation to inhibit the activation of the MAPK kinase (MKK) and prevent activation by phosphorylation. YopJ is also able to block yeast MAPK signaling pathways using this mechani...

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Autores principales: Yi-Heng Hao, Yong Wang, Dara Burdette, Sohini Mukherjee, Gladys Keitany, Elizabeth Goldsmith, Kim Orth
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science (PLoS) 2008-01-01
Colección:PLoS ONE
Acceso en línea:http://europepmc.org/articles/PMC2147050?pdf=render
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