Noonan Syndrome-associated SHP-2/Ptpn11 Mutants Enhance SIRPα and PZR Tyrosyl Phosphorylation and Promote Adhesion-mediated ERK Activation

Noonan syndrome (NS) is an autosomal dominant disorder that is associated with multiple developmental abnormalities. Activated mutations of the protein-tyrosine phosphatase, SHP-2/PTPN11, have been reported in ∼50% of NS cases. Despite being activated, NS-associated SHP-2 mutants require plasma memb...

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Bibliographic Details
Main Authors: Eminaga, Seda, Bennett, Anton M.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2008
Subjects:
Mechanisms of Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2397460/
https://ncbi.nlm.nih.gov/pubmed/18378677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M801382200
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