JAK2 and SHP2 Reciprocally Regulate Tyrosine Phosphorylation and Stability of Proapoptotic Protein ASK1

Previously we have shown that tyrosine 718 of ASK1 when phosphorylated is critical for SOCS1 binding and SOCS1-mediated degradation of ASK1. However, the kinase and phosphatase responsible for phosphorylation and dephosphorylation of ASK1 at Tyr-718 are unknown. In this study, we identified JAK2 and...

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Detalhes bibliográficos
Main Authors: Yu, Luyang, Min, Wang, He, Yun, Qin, Lingfeng, Zhang, Haifeng, Bennett, Anton M., Chen, Hong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2679448/
https://ncbi.nlm.nih.gov/pubmed/19287004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M809740200
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