JAK2 and SHP2 Reciprocally Regulate Tyrosine Phosphorylation and Stability of Proapoptotic Protein ASK1

Previously we have shown that tyrosine 718 of ASK1 when phosphorylated is critical for SOCS1 binding and SOCS1-mediated degradation of ASK1. However, the kinase and phosphatase responsible for phosphorylation and dephosphorylation of ASK1 at Tyr-718 are unknown. In this study, we identified JAK2 and...

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Bibliographic Details
Main Authors: Yu, Luyang, Min, Wang, He, Yun, Qin, Lingfeng, Zhang, Haifeng, Bennett, Anton M., Chen, Hong
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Mechanisms of Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2679448/
https://ncbi.nlm.nih.gov/pubmed/19287004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M809740200
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