PZR Coordinates Shp2 Noonan and LEOPARD Syndrome Signaling in Zebrafish and Mice

Noonan syndrome (NS) is an autosomal dominant disorder caused by activating mutations in the PTPN11 gene encoding Shp2, which manifests in congenital heart disease, short stature, and facial dysmorphia. The complexity of Shp2 signaling is exemplified by the observation that LEOPARD syndrome (LS) pat...

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Detalhes bibliográficos
Main Authors: Paardekooper Overman, Jeroen, Yi, Jae-Sung, Bonetti, Monica, Soulsby, Matthew, Preisinger, Christian, Stokes, Matthew P., Hui, Li, Silva, Jeffrey C., Overvoorde, John, Giansanti, Piero, Heck, Albert J. R., Kontaridis, Maria I., den Hertog, Jeroen, Bennett, Anton M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4135572/
https://ncbi.nlm.nih.gov/pubmed/24865967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00135-14
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