PZR Coordinates Shp2 Noonan and LEOPARD Syndrome Signaling in Zebrafish and Mice

Noonan syndrome (NS) is an autosomal dominant disorder caused by activating mutations in the PTPN11 gene encoding Shp2, which manifests in congenital heart disease, short stature, and facial dysmorphia. The complexity of Shp2 signaling is exemplified by the observation that LEOPARD syndrome (LS) pat...

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Bibliografski detalji
Glavni autori: Paardekooper Overman, Jeroen, Yi, Jae-Sung, Bonetti, Monica, Soulsby, Matthew, Preisinger, Christian, Stokes, Matthew P., Hui, Li, Silva, Jeffrey C., Overvoorde, John, Giansanti, Piero, Heck, Albert J. R., Kontaridis, Maria I., den Hertog, Jeroen, Bennett, Anton M.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2014
Teme:
Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4135572/
https://ncbi.nlm.nih.gov/pubmed/24865967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00135-14
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