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Structures of the rare-cutting restriction endonuclease NotI reveal a novel metal binding fold involved in DNA recognition

The structure of the rare-cutting restriction endonuclease NotI, which recognizes the 8 basepair target 5′-GCGGCCGC-3′, has been solved with and without bound DNA. Because of its specificity (recognizing a site that occurs once per 65kb), NotI is used to generate large genomic fragments and to map D...

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Dettagli Bibliografici
Autori principali: Lambert, Abigail R., Sussman, Django, Shen, Betty, Maunus, Robert, Nix, Jay, Samuelson, James, Xu, Shuang-yong, Stoddard, Barry L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2390919/
https://ncbi.nlm.nih.gov/pubmed/18400177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2008.01.017
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