Conformational change upon ligand binding and dynamics of the PDZ domain from leukemia-associated Rho guanine nucleotide exchange factor

Leukemia-associated Rho guanine nucleotide exchange factor (LARG) is a RhoA-specific guanine nucleotide exchange factor (GEF) that can activate RhoA. The PDZ (PSD-95/Disc-large/ZO-1 homology) domain of LARG interacts with membrane receptors, which can relay extracellular signals to RhoA signal trans...

Full description

Saved in:
Bibliographic Details
Main Authors: Liu, Jiangxin, Zhang, Jiahai, Yang, Yinshan, Huang, Hongda, Shen, Weiqun, Hu, Qi, Wang, Xingsheng, Wu, Jihui, Shi, Yunyu
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2008
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2386735/
https://ncbi.nlm.nih.gov/pubmed/18411422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.073416508
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items