Conformational change upon ligand binding and dynamics of the PDZ domain from leukemia-associated Rho guanine nucleotide exchange factor

Leukemia-associated Rho guanine nucleotide exchange factor (LARG) is a RhoA-specific guanine nucleotide exchange factor (GEF) that can activate RhoA. The PDZ (PSD-95/Disc-large/ZO-1 homology) domain of LARG interacts with membrane receptors, which can relay extracellular signals to RhoA signal trans...

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Detalhes bibliográficos
Main Authors: Liu, Jiangxin, Zhang, Jiahai, Yang, Yinshan, Huang, Hongda, Shen, Weiqun, Hu, Qi, Wang, Xingsheng, Wu, Jihui, Shi, Yunyu
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2386735/
https://ncbi.nlm.nih.gov/pubmed/18411422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.073416508
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