Structure of the Rho-specific guanine nucleotide-exchange factor Xpln

Xpln is a guanine nucleotide-exchange factor (GEF) for Rho GTPases. A Dbl homology (DH) domain followed by a pleckstrin homology (PH) domain is a widely adopted GEF-domain architecture. The Xpln structure solely comprises these two domains. Xpln activates RhoA and RhoB, but not RhoC, although their...

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Autores principales: Murayama, Kazutaka, Kato-Murayama, Miyuki, Akasaka, Ryogo, Terada, Takaho, Yokoyama, Shigeyuki, Shirouzu, Mikako
Formato: Artigo
Lenguaje:Inglês
Publicado: International Union of Crystallography 2012
Materias:
Structural Communications
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3509964/
https://ncbi.nlm.nih.gov/pubmed/23192023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309112045265
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