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Generation of deletion mutants of simian immunodeficiency virus incapable of proviral integration.

Deletion mutants of simian immunodeficiency virus (SIVmac) which were unable to integrate into host cells were generated by removing a portion of the integrase (IN) domain of the pol gene. The resulting plasmid was transfected into HUT-78 and human rhabdomyosarcoma cells. In comparison with the pare...

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Udgivet i:J Virol
Principais autores: Prakash, K, Ranganathan, P N, Mettus, R, Reddy, P, Srinivasan, A, Plotkin, S
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1992
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC238272/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1727479/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.66.1.167-171.1992
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