Generation of deletion mutants of simian immunodeficiency virus incapable of proviral integration.

Deletion mutants of simian immunodeficiency virus (SIVmac) which were unable to integrate into host cells were generated by removing a portion of the integrase (IN) domain of the pol gene. The resulting plasmid was transfected into HUT-78 and human rhabdomyosarcoma cells. In comparison with the pare...

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Veröffentlicht in:	J Virol
Hauptverfasser:	Prakash, K, Ranganathan, P N, Mettus, R, Reddy, P, Srinivasan, A, Plotkin, S
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1992
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC238272/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1727479/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.66.1.167-171.1992
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