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Chimeric tick-borne encephalitis and dengue type 4 viruses: effects of mutations on neurovirulence in mice.

Two new chimeric flaviviruses were constructed from full-length cDNAs that contained tick-borne encephalitis virus (TBEV) CME or ME structural protein genes and the remaining genes derived from dengue type 4 virus (DEN4). Studies involving mice inoculated intracerebrally with the ME chimeric virus i...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Pletnev, A G, Bray, M, Lai, C J
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 1993
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC237883/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8331735/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.67.8.4956-4963.1993
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