NMD is essential for hematopoietic stem and progenitor cells and for eliminating by-products of programmed DNA rearrangements

Nonsense-mediated mRNA decay (NMD) is a post-transcriptional surveillance process that eliminates mRNAs containing premature termination codons (PTCs). NMD has been hypothesized to impact on several aspects of cellular function; however, its importance in the context of a mammalian organism has not...

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Auteurs principaux: Weischenfeldt, Joachim, Damgaard, Inge, Bryder, David, Theilgaard-Mönch, Kim, Thoren, Lina A., Nielsen, Finn Cilius, Jacobsen, Sten Eirik W., Nerlov, Claus, Porse, Bo Torben
Format: Artigo
Langue:Inglês
Publié: Cold Spring Harbor Laboratory Press 2008
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2377192/
https://ncbi.nlm.nih.gov/pubmed/18483223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.468808
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