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Tumor necrosis factor restricts hematopoietic stem cell activity in mice: involvement of two distinct receptors

Whereas maintenance of hematopoietic stem cells (HSCs) is a requisite for life, uncontrolled expansion of HSCs might enhance the propensity for leukemic transformation. Accordingly, HSC numbers are tightly regulated. The identification of physical cellular HSC niches has underscored the importance o...

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Autori principali: Pronk, Cornelis J.H., Veiby, Ole Petter, Bryder, David, Jacobsen, Sten Eirik W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3149225/
https://ncbi.nlm.nih.gov/pubmed/21768269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20110752
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