Human and Murine Hematopoietic Stem Cell Aging Is Associated with Functional Impairments and Intrinsic Megakaryocytic/Erythroid Bias

Aging within the human hematopoietic system associates with various deficiencies and disease states, including anemia, myeloid neoplasms and reduced adaptive immune responses. Similar phenotypes are observed in mice and have been linked to alterations arising at the hematopoietic stem cell (HSC) lev...

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Udgivet i:PLoS One
Main Authors: Rundberg Nilsson, Alexandra, Soneji, Shamit, Adolfsson, Sofia, Bryder, David, Pronk, Cornelis Jan
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4930192/
https://ncbi.nlm.nih.gov/pubmed/27368054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0158369
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