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High c-Kit expression identifies hematopoietic stem cells with impaired self-renewal and megakaryocytic bias
Hematopoietic stem cells (HSCs) are heterogeneous with respect to their self-renewal, lineage, and reconstitution potentials. Although c-Kit is required for HSC function, gain and loss-of-function c-Kit mutants suggest that even small changes in c-Kit signaling profoundly affect HSC function. Herein...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3920569/ https://ncbi.nlm.nih.gov/pubmed/24446491 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20131128 |
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