Phosphorylation of Serine 248 of C/EBPα Is Dispensable for Myelopoiesis but Its Disruption Leads to a Low Penetrant Myeloid Disorder with Long Latency

BACKGROUND: Transcription factors play a key role in lineage commitment and differentiation of stem cells into distinct mature cells. In hematopoiesis, they regulate lineage-specific gene expression in a stage-specific manner through various physical and functional interactions with regulatory prote...

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Detalhes bibliográficos
Main Authors: Hasemann, Marie S., Schuster, Mikkel B., Frank, Anne-Katrine, Theilgaard-Mönch, Kim, Pedersen, Thomas Å., Nerlov, Claus, Porse, Bo T.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3371045/
https://ncbi.nlm.nih.gov/pubmed/22715416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0038841
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