CpG methylation of MGMT and hMLH1 promoter in hepatocellular carcinoma associated with hepatitis viral infection

Inactivations of DNA repair genes, O(6)-methylguanine-DNA methyltransferase (MGMT) and hMLH1, by promoter hypermethylation have been reported in several types of primary human neoplasia. This epigenetic inactivation mechanism remains elusive in hepatocellular carcinoma (HCC). To investigate the rela...

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Bibliografski detalji
Glavni autori: Matsukura, S, Soejima, H, Nakagawachi, T, Yakushiji, H, Ogawa, A, Fukuhara, M, Miyazaki, K, Nakabeppu, Y, Sekiguchi, M, Mukai, T
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2003
Teme:
Molecular and Cellular Pathology
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2377174/
https://ncbi.nlm.nih.gov/pubmed/12592365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6600743
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