Hypermethylation of the hMLH1 gene promoter in solitary and multiple gastric cancers with microsatellite instability

Human cancers with a high frequency microsatellite instability phenotype develop due to defects in DNA mismatch repair genes. Silencing of a DNA mismatch repair gene, hMLH1 gene, by promoter hypermethylation is a frequent cause of the microsatellite instability-H phenotype. Using methylation specifi...

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Bibliographic Details
Main Authors: Sakata, K, Tamura, G, Endoh, Y, Ohmura, K, Ogata, S, Motoyama, T
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2002
Subjects:
Molecular and Cellular Pathology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2375269/
https://ncbi.nlm.nih.gov/pubmed/11870538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6600076
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