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Hypermethylation of the hMLH1 gene promoter in solitary and multiple gastric cancers with microsatellite instability
Human cancers with a high frequency microsatellite instability phenotype develop due to defects in DNA mismatch repair genes. Silencing of a DNA mismatch repair gene, hMLH1 gene, by promoter hypermethylation is a frequent cause of the microsatellite instability-H phenotype. Using methylation specifi...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2375269/ https://ncbi.nlm.nih.gov/pubmed/11870538 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6600076 |
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