CpG methylation of MGMT and hMLH1 promoter in hepatocellular carcinoma associated with hepatitis viral infection

Inactivations of DNA repair genes, O(6)-methylguanine-DNA methyltransferase (MGMT) and hMLH1, by promoter hypermethylation have been reported in several types of primary human neoplasia. This epigenetic inactivation mechanism remains elusive in hepatocellular carcinoma (HCC). To investigate the rela...

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Hlavní autoři: Matsukura, S, Soejima, H, Nakagawachi, T, Yakushiji, H, Ogawa, A, Fukuhara, M, Miyazaki, K, Nakabeppu, Y, Sekiguchi, M, Mukai, T
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2003
Témata:
Molecular and Cellular Pathology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2377174/
https://ncbi.nlm.nih.gov/pubmed/12592365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6600743
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