CpG methylation of MGMT and hMLH1 promoter in hepatocellular carcinoma associated with hepatitis viral infection

Inactivations of DNA repair genes, O(6)-methylguanine-DNA methyltransferase (MGMT) and hMLH1, by promoter hypermethylation have been reported in several types of primary human neoplasia. This epigenetic inactivation mechanism remains elusive in hepatocellular carcinoma (HCC). To investigate the rela...

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Detalhes bibliográficos
Main Authors: Matsukura, S, Soejima, H, Nakagawachi, T, Yakushiji, H, Ogawa, A, Fukuhara, M, Miyazaki, K, Nakabeppu, Y, Sekiguchi, M, Mukai, T
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2003
Assuntos:
Molecular and Cellular Pathology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2377174/
https://ncbi.nlm.nih.gov/pubmed/12592365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6600743
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