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Phenotype-genotype studies in kuru: Implications for new variant Creutzfeldt–Jakob disease

The PRNP polymorphic (methionine/valine) codon 129 genotype influences the phenotypic features of transmissible spongiform encephalopathy. All tested cases of new variant Creutzfeldt–Jakob disease (nvCJD) have been homozygous for methionine, and it is conjectural whether different genotypes, if they...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Cervenáková, Larisa, Goldfarb, Lev G., Garruto, Ralph, Lee, Hee-Suk, Gajdusek, D. Carleton, Brown, Paul
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1998
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC23768/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9789072/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.22.13239
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