The 200- and 150-kDa neurofilament proteins react with IgG autoantibodies from chimpanzees with kuru or Creutzfeldt-Jakob disease; a 62-kDa neurofilament-associated protein reacts with sera from sheep with natural scrapie.

Sera from 46 chimpanzees with spongiform encephalopathy (18 kuru, 28 Creutzfeldt-Jakob disease) and sera from 12 sheep with natural scrapie were tested for reactivity with immunoblots of neurofilament preparations obtained from mouse brain. The sera from the chimpanzees reacted mainly with the 200-...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Toh, B H, Gibbs, C J, Gajdusek, D C, Tuthill, D D, Dahl, D
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1985
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Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC397895/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3923483/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.82.11.3894
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