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Phenotype-genotype studies in kuru: Implications for new variant Creutzfeldt–Jakob disease

The PRNP polymorphic (methionine/valine) codon 129 genotype influences the phenotypic features of transmissible spongiform encephalopathy. All tested cases of new variant Creutzfeldt–Jakob disease (nvCJD) have been homozygous for methionine, and it is conjectural whether different genotypes, if they...

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Autori principali: Cervenáková, Larisa, Goldfarb, Lev G., Garruto, Ralph, Lee, Hee-Suk, Gajdusek, D. Carleton, Brown, Paul
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences 1998
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC23768/
https://ncbi.nlm.nih.gov/pubmed/9789072
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