Phenotype-genotype studies in kuru: Implications for new variant Creutzfeldt–Jakob disease

The PRNP polymorphic (methionine/valine) codon 129 genotype influences the phenotypic features of transmissible spongiform encephalopathy. All tested cases of new variant Creutzfeldt–Jakob disease (nvCJD) have been homozygous for methionine, and it is conjectural whether different genotypes, if they...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Cervenáková, Larisa, Goldfarb, Lev G., Garruto, Ralph, Lee, Hee-Suk, Gajdusek, D. Carleton, Brown, Paul
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 1998
Sujets:	Biological Sciences
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC23768/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9789072/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.22.13239
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