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Phosphorylation of MDMX Mediated by Akt Leads to Stabilization and Induces 14-3-3 Binding
The critical tumor suppressor p53 is mutated or functionally inactivated in nearly all cancers. We have shown previously that the MDM2-MDMX complex functions as an integral unit in targeting p53 for degradation. Here we identify the small protein 14-3-3 as a binding partner of MDMX, which binds at t...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2376244/ https://ncbi.nlm.nih.gov/pubmed/18356162 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M710030200 |
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