Role of JNK Translocation to Mitochondria Leading to Inhibition of Mitochondria Bioenergetics in Acetaminophen-induced Liver Injury

Previously, we demonstrated JNK plays a central role in acetaminophen (APAP)-induced liver injury (Gunawan, B. K., Liu, Z. X., Han, D., Hanawa, N., Gaarde, W. A., and Kaplowitz, N. (2006) Gastroenterology 131, 165–178). In this study, we examine the mechanism involved in activating JNK and explore t...

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Detalhes bibliográficos
Main Authors: Hanawa, Naoko, Shinohara, Mie, Saberi, Behnam, Gaarde, William A., Han, Derick, Kaplowitz, Neil
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2376214/
https://ncbi.nlm.nih.gov/pubmed/18337250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M708916200
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