Role of JNK Translocation to Mitochondria Leading to Inhibition of Mitochondria Bioenergetics in Acetaminophen-induced Liver Injury

Previously, we demonstrated JNK plays a central role in acetaminophen (APAP)-induced liver injury (Gunawan, B. K., Liu, Z. X., Han, D., Hanawa, N., Gaarde, W. A., and Kaplowitz, N. (2006) Gastroenterology 131, 165–178). In this study, we examine the mechanism involved in activating JNK and explore t...

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Bibliografske podrobnosti
Main Authors: Hanawa, Naoko, Shinohara, Mie, Saberi, Behnam, Gaarde, William A., Han, Derick, Kaplowitz, Neil
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2008
Teme:
Mechanisms of Signal Transduction
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2376214/
https://ncbi.nlm.nih.gov/pubmed/18337250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M708916200
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