Role of JNK Translocation to Mitochondria Leading to Inhibition of Mitochondria Bioenergetics in Acetaminophen-induced Liver Injury

Previously, we demonstrated JNK plays a central role in acetaminophen (APAP)-induced liver injury (Gunawan, B. K., Liu, Z. X., Han, D., Hanawa, N., Gaarde, W. A., and Kaplowitz, N. (2006) Gastroenterology 131, 165–178). In this study, we examine the mechanism involved in activating JNK and explore t...

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Détails bibliographiques
Auteurs principaux: Hanawa, Naoko, Shinohara, Mie, Saberi, Behnam, Gaarde, William A., Han, Derick, Kaplowitz, Neil
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2008
Sujets:
Mechanisms of Signal Transduction
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2376214/
https://ncbi.nlm.nih.gov/pubmed/18337250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M708916200
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