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Role of the cAMP sensor Epac as a determinant of K(ATP) channel ATP sensitivity in human pancreatic β-cells and rat INS-1 cells

Protein kinase A (PKA)-independent actions of adenosine 3′,5′-cyclic monophosphate (cAMP) are mediated by Epac, a cAMP sensor expressed in pancreatic β-cells. Evidence that Epac might mediate the cAMP-dependent inhibition of β-cell ATP-sensitive K(+) channels (K(ATP)) was provided by one prior study...

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Bibliografski detalji
Glavni autori: Kang, Guoxin, Leech, Colin A, Chepurny, Oleg G, Coetzee, William A, Holz, George G
Format: Artigo
Jezik:Inglês
Izdano: Blackwell Science Inc 2008
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2375670/
https://ncbi.nlm.nih.gov/pubmed/18202100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2007.143818
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