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Role of the cAMP sensor Epac as a determinant of K(ATP) channel ATP sensitivity in human pancreatic β-cells and rat INS-1 cells
Protein kinase A (PKA)-independent actions of adenosine 3′,5′-cyclic monophosphate (cAMP) are mediated by Epac, a cAMP sensor expressed in pancreatic β-cells. Evidence that Epac might mediate the cAMP-dependent inhibition of β-cell ATP-sensitive K(+) channels (K(ATP)) was provided by one prior study...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Science Inc
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2375670/ https://ncbi.nlm.nih.gov/pubmed/18202100 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2007.143818 |
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