Tumour targeting of humanised cross-linked divalent-fab′ antibody fragments: a clinical phase I/II study

Antibody engineering has made it possible to design antibodies with optimal characteristics for delivery of radionuclides for tumour imaging and therapy. A humanised divalent-Fab′ cross-linked with a bis-maleimide linker referred to as humanised divalent-Fab′ maleimide was produced as a result of th...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Casey, J L, Napier, M P, King, D J, Pedley, R B, Chaplin, L C, Weir, N, Skelton, L, Green, A J, Hope-Stone, L D, Yarranton, G T, Begent, R H J
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2002
Schlagworte:
Clinical
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2375360/
https://ncbi.nlm.nih.gov/pubmed/11986771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6600198
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