Expression, purification and characterization of a mouse-human chimeric antibody and chimeric Fab' fragment.

B72.3 is a mouse monoclonal antibody against a tumour-associated antigen, TAG72, which recognizes breast, ovarian and colorectal tumour tissue. A mouse-human chimeric version of B72.3 has been expressed in Chinese-hamster ovary cells. This molecule has the binding specificity of B72.3 and constant r...

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Detalhes bibliográficos
Main Authors: King, D J, Adair, J R, Angal, S, Low, D C, Proudfoot, K A, Lloyd, J C, Bodmer, M W, Yarranton, G T
Formato: Artigo
Idioma:Inglês
Publicado em: 1992
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1130685/
https://ncbi.nlm.nih.gov/pubmed/1736881
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