Clearance of yttrium-90-labelled anti-tumour antibodies with antibodies raised against the 12N4 DOTA macrocycle.

Radioimmunotherapy (RIT) is currently limited by toxicity to normal tissues as a result of prolonged circulating radioantibody in the blood. In this study, the use of a clearing antibody was investigated (second antibody) in an attempt to reduce blood background levels of [90Y]A5B7 immunoglobulin G...

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Hlavní autoři: Casey, J. L., King, D. J., Pedley, R. B., Boden, J. A., Boden, R., Chaplin, L. C., Dorning, M., Begent, R. H.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group|1 1998
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2063187/
https://ncbi.nlm.nih.gov/pubmed/9823971
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