Enhanced tumour specificity of an anti-carcinoembrionic antigen Fab' fragment by poly(ethylene glycol) (PEG) modification.

Polyethylene glycol (PEG) modification of a chimeric Fab' fragment (F9) of A5B7 (alpha-CEA), using an improved coupling method, increases its specificity for subcutaneous LS174T tumours. PEGylation increased the area under the concentration-time curve (AUC0-144) in all tissues but there were si...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Delgado, C., Pedley, R. B., Herraez, A., Boden, R., Boden, J. A., Keep, P. A., Chester, K. A., Fisher, D., Begent, R. H., Francis, G. E.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 1996
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2074309/
https://ncbi.nlm.nih.gov/pubmed/8546903
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