[Arg(6), D-Trp(7,9), N(me)Phe(8)]-substance P (6–11) (antagonist G) inducesP-1 transcription and sensitizes cells to chemotherapy

Eitemau Tebyg

• [Arg(6),D-Trp(7,9),N(me)Phe(8)]-substance P (6–11) activates JNK and induces apoptosis in small cell lung cancer cells via an oxidant-dependent mechanism
  gan: MacKinnon, A C, et al.
  Cyhoeddwyd: (1999)
• Increased gastrin-releasing peptide (GRP) receptor expression in tumour cells confers sensitivity to [Arg(6),D-Trp(7,9),N(me)Phe(8)]-substance P (6–11)-induced growth inhibition
  gan: Waters, C M, et al.
  Cyhoeddwyd: (2003)
• Targeting V(1A)-vasopressin receptors with [Arg(6), D-Trp(7,9), N(me)Phe(8)]-substance P (6-11) identifies a strategy to develop novel anti-cancer therapies
  gan: MacKinnon, Alison C, et al.
  Cyhoeddwyd: (2009)
• Metabolism of the broad-spectrum neuropeptide growth factor antagonist: [D-Arg1, D-Phe5, D-Trp7,9, Leu11]-substance P.
  gan: Jones, D. A., et al.
  Cyhoeddwyd: (1996)
• In vitro effects of substance P analogue [D-Arg1, D-Phe5, D-Trp7,9, Leu11] substance P on human tumour and normal cell growth.
  gan: Everard, M. J., et al.
  Cyhoeddwyd: (1992)