[Arg(6), D-Trp(7,9), N(me)Phe(8)]-substance P (6–11) (antagonist G) inducesP-1 transcription and sensitizes cells to chemotherapy

[Arg(6), D-Trp(7,9), N(me)Phe(8)]-substance P (6–11) (antagonist G) inhibits small cell lung cancer (SCLC) growth and is entering Phase II clinical investigation for the treatment of SCLC. As well as acting as a neuropeptide receptor antagonist, antagonist G stimulates c-jun-N-terminal kinase (JNK)...

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Detalhes bibliográficos
Main Authors: MacKinnon, A C, Waters, C, Rahman, I, Harani, N, Rintoul, R, Haslett, C, Sethi, T
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2000
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2374683/
https://ncbi.nlm.nih.gov/pubmed/10970698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1054/bjoc.2000.1362
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