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[Arg(6), D-Trp(7,9), N(me)Phe(8)]-substance P (6–11) (antagonist G) inducesP-1 transcription and sensitizes cells to chemotherapy
[Arg(6), D-Trp(7,9), N(me)Phe(8)]-substance P (6–11) (antagonist G) inhibits small cell lung cancer (SCLC) growth and is entering Phase II clinical investigation for the treatment of SCLC. As well as acting as a neuropeptide receptor antagonist, antagonist G stimulates c-jun-N-terminal kinase (JNK)...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group
2000
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2374683/ https://ncbi.nlm.nih.gov/pubmed/10970698 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1054/bjoc.2000.1362 |
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