Targeting V(1A)-vasopressin receptors with [Arg(6), D-Trp(7,9), N(me)Phe(8)]-substance P (6-11) identifies a strategy to develop novel anti-cancer therapies

BACKGROUND AND PURPOSE: The anti-cancer agent [Arg(6), D-Trp(7,9), N(me)Phe(8)]-substance P (6-11) (SP-G) modulates gastrin releasing peptide (GRP) and arginine vasopressin signalling in small cell lung cancer cells leading to growth arrest and apoptosis. We have shown that SP-G acts as a biased ago...

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Detalhes bibliográficos
Main Authors: MacKinnon, Alison C, Tufail-Hanif, Uzma, Wheatley, Mark, Rossi, Adriano G, Haslett, Christopher, Seckl, Michael, Sethi, Tariq
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2009
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2697774/
https://ncbi.nlm.nih.gov/pubmed/19133990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2008.00003.x
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