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In vitro effects of substance P analogue [D-Arg1, D-Phe5, D-Trp7,9, Leu11] substance P on human tumour and normal cell growth.

Analogues of the neurotransmitter substance P (SP) can interact with neuropeptide receptors, and are reported to inhibit growth of small cell lung cancer cell lines (SCLC CLs). We found [D-Arg1, D-Phe5, D-Trp7,9, Leu11] substance P (D-Phe5SP) significantly inhibited DNA synthesis by 10/10 human tumo...

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Bibliografiske detaljer
Main Authors: Everard, M. J., Macaulay, V. M., Miller, J. L., Smith, I. E.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 1992
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1977586/
https://ncbi.nlm.nih.gov/pubmed/1373071
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