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Deletion of Histone Deacetylase 3 reveals critical roles in S-phase progression and DNA damage control

Histone deacetylases (HDAC) are enzymes that modify key residues in histones to regulate chromatin architecture, and play a vital role in cell survival, cell cycle progression, and tumorigenesis. To understand the function of Hdac3, a critical component of the N-CoR/SMRT repression complex, a condit...

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Autores principales: Bhaskara, Srividya, Chyla, Brenda J., Amann, Joseph M., Knutson, Sarah K., Cortez, David, Sun, Zu-Wen, Hiebert, Scott W.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2373760/
https://ncbi.nlm.nih.gov/pubmed/18406327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2008.02.030
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