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Deacetylase activity of histone deacetylase 3 is required for productive VDJ recombination and B-cell development
Histone deacetylase 3 (HDAC3) is the catalytic component of NCoR/SMRT corepressor complexes that mediate the actions of transcription factors implicated in the regulation of B-cell development and function. We crossed Hdac3 conditional knockout mice with Mb1-Cre knockin animals to delete Hdac3 in ea...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5559004/ https://ncbi.nlm.nih.gov/pubmed/28739911 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1701610114 |
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