Deacetylase activity of histone deacetylase 3 is required for productive VDJ recombination and B-cell development

Histone deacetylase 3 (HDAC3) is the catalytic component of NCoR/SMRT corepressor complexes that mediate the actions of transcription factors implicated in the regulation of B-cell development and function. We crossed Hdac3 conditional knockout mice with Mb1-Cre knockin animals to delete Hdac3 in ea...

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Библиографические подробности
Опубликовано в: :Proc Natl Acad Sci U S A
Главные авторы: Stengel, Kristy R., Barnett, Kelly R., Wang, Jing, Liu, Qi, Hodges, Emily, Hiebert, Scott W., Bhaskara, Srividya
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2017
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5559004/
https://ncbi.nlm.nih.gov/pubmed/28739911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1701610114
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